Berberine helps the brain by acting as an antioxidant, reducing neuroinflammation and oxidative stress, promoting autophagy to clear toxic proteins, improving cerebral blood flow, and protecting the integrity of the blood-brain barrier. It has shown potential in preclinical studies for neurodegenerative diseases like Alzheimer’s and Parkinson’s, as well as psychiatric conditions like depression and anxiety.
Ingredients
Active ingredient: Berberine HCL 1.5mg per serving
Other ingredients: Distilled Water, Propanediol (plant-based), Cyclodextrin, Organic Xylitol & Spearmint Essential Oil.
This product does not contain Alcohol, Artificial Preservatives, PEGs, PG, Polysorbates & Glycerin.
Indications
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Cognitive Enhancement: To support improved cognitive function, including memory, focus and mental clarity.*
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Neuroinflammatory Conditions: To help reduce brain inflammation associated with cognitive decline.*
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Mood Regulation: To aid in stabilizing mood and supporting emotional balance.*
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Neuroprotection: To guard against oxidative stress and cellular damage in the brain, potentially lowering the risk of neurodegenerative diseases.*
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Cognitive Recovery: To support neuronal health and recovery following periods of stress, illness, or age-related cognitive changes.*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
How does it work
The Nasal Spray Solution: The “Nose-to-Brain” Pathway
A nasal spray bypasses the Blood Brain Barrier entirely by utilizing the olfactory and trigeminal nerve pathways.
The intranasal route provides a direct pathway to different regions of the brain, bypassing the Blood-Brain Barrier and First Pass Metabolism (avoiding digestion and liver metabolism). The use of cyclodextrin delivery system in our product allows the Berberine to be absorbed through the nasal mucosa and travel via olfactory and trigeminal nerves directly into the brain. This allows for targeted delivery, higher brain concentrations, and enhanced neuroprotective effects compared to oral administration.*
- Reduces Neuroinflammation and Oxidative Stress: Berberine has antioxidant and anti-inflammatory properties that help protect neurons from damage such as protecting dopamine-producing neurons from toxins and degeneration, potentially slowing Parkinson’s disease progression.* It can also reduce the buildup of toxic proteins and promote its clearance like beta-amyloid (Aβ), and inhibit Tau tangles, both of which are implicated in Alzheimer’s disease.*
- Improves Cerebral Blood Flow: It promotes the growth of new blood vessels (angiogenesis) and improves blood supply to the brain, which is crucial for cognitive function and neuronal survival.*
- Protects the Blood-Brain Barrier (BBB): The compound can help maintain the integrity and function of the BBB, which is essential for protecting the central nervous system.*
- Supports Autophagy: Berberine can induce autophagy, a cellular process that helps clear out damaged or misfolded proteins from neuronal cells.*
- Modulates Signaling Pathways: It affects various cellular signaling pathways, including those involved in inflammation, oxidative stress, apoptosis (programmed cell death), and anti-proliferative effects, all of which are central to neurological health.*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Who uses it
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Adults Experiencing Cognitive Decline: Individuals noticing age-related memory lapses, brain fog, or decreased mental clarity.*
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Those Seeking Neuroprotection: People with a family history of neurodegenerative diseases aiming for proactive brain health.*
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Individuals Under High Stress: Professionals or students needing enhanced focus, mood stability, and resilience to mental fatigue.*
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Patients with Neuroinflammatory Conditions: Those seeking support for conditions linked to brain inflammation (always under medical supervision).*
- Healthy adults: Individuals who seek to maintain healthy cognitive functions. *
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
How to use it
1. Remove cap and safety clip.
2. Point the nozzle upwards when spraying. Nozzle should NEVER be pointed horizontally.
- Insert the nozzle pointing upwards deep in each nostril. Do not tilt head backwards when spraying.
- Press fully and firmly to spray deep into the back of each nostril. Inhale the solution
- If done correctly, there should be no excess dripping out from the nose. Should there be any excess, wipe away.
3. After use, wipe the nozzle clean and secure the cap after use. Do not share applicators with others.
Directions and Warnings
For adult use only. Shake well. One spray deep in each nostril up to 3x daily. Wipe nozzle clean after use.
Caution: Do not use during pregnancy & nursing. Keep out of reach of children. Consult a physician before use if on medications or have a medical condition. If irritation occurs, discontinue use. Do not exceed recommended dose.
Shipping details
Delivery destinations
We ship orders to most countries worldwide. If your country is available when placing your order, we will deliver to your country.
All deliveries are tracked, using our preferred shipping partner for each country. You will receive a dispatch confirmation which will include a tracking reference.
Delivery times are estimates and are subject to change, including the impact of COVID-19 pandemic and any customs clearance processing requirements of your country of importation.
Delivery charges
Delivery charges are added to the value of your order and are calculated based on your shipping address.
For countries beyond Singapore, international shipping rates apply.
Expedited delivery
All deliveries are shipped by our shipping partner for each country to optimize the transit time and the cost of delivery. Currently, we are unable to offer special expedited delivery.
Receiving your order
You may need to sign to receive your order or have a safe and secure place available so that our shipping partner can leave your order at the shipping address if you are not available to receive it in person.
If there is not a safe and secure place to leave your order at your shipping address, our shipping partner will contact you to discuss alternative arrangements.
Please use the optional “Company Name / Order Notes” box on the checkout page to add further details for the safe receipt of your delivery. However, we cannot guarantee our shipping partner will always be able to comply with these special instructions. It is important that the address details are accurate and completed fully.
Deliveries to PO Box and shared addresses
Some shipping partners cannot make deliveries to PO Box addresses so it is recommended that all delivery addresses are physical street addresses.
We do not deliver to P.O. boxes, army camps, chalets, islands or third-party couriers. Any orders to be sent to a shared address, such as shared boxes or third-party couriers, are entirely at the risk of the consumer. Therefore, we cannot accept any liability for orders that fail to arrive at such destinations or are damaged on receipt.
Bulk orders
The website www.arrezt.com is for consumer and end-user purchasers only. You must not offer or re-sell products bought from this website, without our prior written approval. As such, we reserve the right to cancel excessive orders without notice. If you wish to make a commercial or bulk order, please send an enquiry to admin@arrezt.com.
Returns policy
Cancelling an order for an unwanted product
If you notice a mistake, please inform admin@arrezt.com as soon as possible. Although we will try our best to cancel your order, we cannot guarantee that we will be able to stop your order in time to prevent it from being dispatched. If your order has not been dispatched, you will be refunded promptly for the full amount paid.
Return of defective products
You are covered for defective products in accordance with laws that apply to our sale of the products to you. We will do our best to assist you quickly and efficiently. All defective products will be evaluated before being processed for replacement or refund. Please let us know immediately if you have received a defective product.
Please email admin@arrezt.com to initiate the returns procedure with the following information within 30 days from the date of delivery:
i) Your order reference number
ii) Photos of the defect
Our Customer Care team will get in touch with you as soon as possible and assist you.
Disclaimer
Disclaimer Regarding Health Information: General information about health issues provided on this website is provided for informational and/or educational purposes only. It is not a replacement for medical advice, medical training, medical assessment or treatment of medical conditions. For individuals, the information is not intended to replace or override information and/or advice provided by an individual’s physician or other healthcare providers. Individuals are encouraged to consult a qualified medical or other healthcare provider before making any decision or taking any action that might affect their health.
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